Disappearance of lupus anticoagulant after allogeneic bone marrow transplantation

Lupus anticoagulant antibodies have never been reported to disappear after either allogeneic or autologous bone marrow transplantation in humans. We r eport the first case of disappearance of lupus anticoagulant antibodies in a patient without systemic lupus erythematosus or clinical evidence of othe r autoimmune disorders, who received an allogeneic bone marrow transplant a s treatment for chronic myeloid leukemia. Although marrow transplantation i s not a recognized therapy for antiphospholipid syndrome, our observation s hould be considered another example of the capability of intensive chemo-ra diotherapy followed by stem cell transplantation to ablate a pathologic mar row clone resulting in an autoimmune disorder and improve, Or even cure, so me severe autoimmune diseases.