Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

GVHD is one of the most frequent complications of BMT and recently nephroti c syndrome (NS) has been described as a manifestation of chronic GVHD, Here , we present an AA patient who developed NS 1 year after BMT when cyclospor ine was stopped. Renal biopsy showed focal sclerosis associated with membra nous deposits. He also had other clinical manifestations of chronic GVHD: s icca-like syndrome and colestasis, After 15 days of CsA therapy, he experie nced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.