Cytogenetic changes in two cases of subependymal giant-cell astrocytoma

Cytogenetic analysis of subependymal giant-cell astrocytomas (SEGAs) from t wo patients presenting the clinical symptoms of tuberous sclerosis complex (TSC) revealed clonal chromosomal changes, resulting in the partial loss of chromosome 22q in both tumors. Immunohistochemically, tumors exhibited fea tures of glial differentiation, while ultrastructural studies identified th e characteristic paracrystalline inclusions within the tumor cells. To our knowledge, it is the first cytogenetic description of SEGAs associated with TSC. (C) Elsevier Science Inc., 1999. All rights reserved.