Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland

We present the cytogenetic, interphase fluorescence in-situ hybridization ( FISH) and DNA content findings in a clinically aggressive adenoid cystic ca rcinoma (ADCC) of the parotid gland. The tumor manifested diploid chromosom al and DNA content by cytogenetic, interphase FISH and flow cytometry. G-ba nding analysis revealed inv(5)(p15.2q33) and t(6;15)(q25;q15) as the only s tructural alterations in all 30 metaphases examined. The limited structural abnormalities found in this recurrent lesion suggest that they may constit ute a primary or early event in the development of this tumor, The involvem ent of 6q region in our tumor and in some of the previously reported ADCC s upports the association between this region and the evolution of at least a subset of these tumors. (C) Elsevier Science Inc., 1999. All rights reserv ed.