Conformational studies on 2-(4-aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and their fluorine derivatives

Authors
Zhang, HY Zhang, LR Ma, LT Zhang, LH Cui, YX Liu, XH
Citation
Hy. Zhang et al., Conformational studies on 2-(4-aminocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and their fluorine derivatives, CHEM J CH U, 19(11), 1998, pp. 1767-1770
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN journal
02510790 → ACNP
Volume
19
Issue
11
Year of publication
1998
Pages
1767 - 1770
Database
ISI
SICI code
0251-0790(199811)19:11<1767:CSO2>2.0.ZU;2-W
Abstract
Employing computer-aided molecule simulation, the conformations of 2-(4-ami nocarbonyl-2-thiazoyl)-1,4-anhydro-L-xylitols and their fluorine derivative s have been studied. The results obtained from calculation show that these novel isomeric C-nucleosides favor the S conformation. NMR study and crysta l X-ray analysis of these compounds coincidentally point to S type furanose conformation.