H. Kashiwase et al., A new fluoroquinolone derivative exhibits inhibitory activity against human immunodeficiency virus type 1 replication, CHEMOTHERA, 45(1), 1999, pp. 48-55
The inhibitory activity of several fluoroquinolone antibiotics against huma
n immunodeficiency virus type 1 (HIV-1) replication was investigated. R-717
62, (+/-) 9-fluoro-3-fluoromethyl-2,3-dihydro-10-[4-(2-pyridyl)-1-piperazin
yl] -7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, protected
MT-4 cells from HIV-l-induced cytopathic effects. Furthermore, the compoun
d inhibited virus replication both in acutely and in chronically HIV-l-infe
cted cells. On the other hand, ofloxacin, levofloxacin, ciprofloxacin, norf
loxacin and enoxacin, that were previously reported to be protective agains
t HIV-l-induced cytopathic effects, did not show any protective activity in
our assay system, These results indicate that R-71762 is a novel inhibitor
of HIV-1 replication and is effective even in HIV-1 chronically infected c
ells.