Local and systemic control after ablative and limb sparing surgery in patients with osteosarcoma

Limb salvage surgery in patients with osteosarcoma is reported to cause a h igher rate of local recurrences with a poorer chance of survival. It was th e aim of the study to analyze differences between ablative and limb sparing surgery in patients with osteosarcoma who are treated with chemotherapy wi th respect to local and systemic tumor control and to determine independent prognostic factors. One hundred thirty consecutive patients younger than t he age of 21 years who were operated on at the authors' institution for ost eosarcoma of the extremities were reviewed. Histologic evaluations of surgi cal margins according to Enneking and coworkers revealed mostly wide (n = 1 09) and radical (n = 10) resection margins. The 5-year disease free surviva l rate was 60% for those patients treated by amputation and 71% for those t reated by limb salvage. The overall local recurrence rate was 2.3%; 4.3% fo r ablation but only 1.2% for limb sparing surgeries. Multivariate analysis showed an independent effect of tumor volume, response to chemotherapy, and as expected, metastases at the time of diagnosis on overall survival. Thes e data indicate that in patients where wide or radical tumor resection can be achieved, no difference in the outcome between ablative and limb sparing surgery occurred in local and systemic tumor control.