Tissue response to an epoxy resin-based root canal sealer

The objective of the present study was to evaluate two different types of r oot canal sealers: AH Plus (an epoxy resin-based sealer) and Fill Canal (a zinc oxide-eugenol based sealer). A total of 34 root canals with vital pulp from dogs' premolars were used. After instrumentation, the root canals wer e filled with gutta-percha and AH Plus or gutta-percha and Fill Canal seale rs using a classical technique of lateral condensation. After histological processing, the sections were stained with hematoxylineosin or Mallory's tr ichrome stain. Inflammatory cells or areas of necrosis were not associated with AH Plus. Hard tissue formation apically to the material was observed i n 14 specimens. The Fill Canal sealer presented an inflammatory response of moderate intensity in the periapical region, mainly adjacent to the materi al.