Stromal sarcoma arising on endometriosis. A clinicopathological and immunohistochemical study of 4 cases

Citation
A. Kondi-paphitis et al., Stromal sarcoma arising on endometriosis. A clinicopathological and immunohistochemical study of 4 cases, EUR J GYN O, 19(6), 1998, pp. 588-590
Citations number
11
Categorie Soggetti
Reproductive Medicine
Journal title
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
ISSN journal
03922936 → ACNP
Volume
19
Issue
6
Year of publication
1998
Pages
588 - 590
Database
ISI
SICI code
0392-2936(1998)19:6<588:SSAOEA>2.0.ZU;2-R
Abstract
The development of stromal sarcomas on the foci of endometriosis is extreme ly rare and the differential diagnosis from other tumors of myogenic, vascu lar, hemopoietic or epithelial origin may present great diagnostic difficul ties. We investigated the clinicopathological and immunohistochemical chara cteristics of 4 cases of endometrial stromal sarcoma. th:lt developed on en dometriotic foci of the uterus, vagina and omentum. Thye were classed as hi gh grade (1/4) or low grade (3/4) malignant potential tumors, according to their mitotic activity. Immunohistochemically these tumors gave a positive reaction to vimentin, but were negative to desmin, smooth muscle actin, fac tor VIII, EMA and LCA. These characteristics permit their identification an d a proper therapeutic approach.