(1S,3R)-ACPD, a metabotropic glutamate receptor agonist, enhances damage after global ischaemia

There are opposing results in the literature concerning the influence of (1 S,3 R)-ACPD [(1S,3 R)-1-aminocyclopentane-1,3-dicarboxylate: group I/II me tabotropic glutamate receptor agonist) on neurodegeneration, showing both e nhancement and reduction of damage. We examined the effects of (IS,3R)-ACPD , given in Various application schedules, on global ischaemia in gerbils. T he most pronounced effect was a significant increase of hippocampal damage when the drug was applied at 20 mg/kg i.p. pre ischaemia. All other experim ents with lower concentrations (0.02-2 mg/kg), other time schedules (post-i schaemic application) or co-application of a selective group I metabotropic glutamate receptor antagonist (4-CPG: (S)-4-carboxyphenylglycine), had no influence on neuronal density. (C) 1999 Elsevier Science B.V. All rights re served.