Endothelin ETA receptor antagonist reverses the inhibitory effect of platelet-derived growth factor on cytokine-induced nitric oxide production

Citation
J. Hirahashi et al., Endothelin ETA receptor antagonist reverses the inhibitory effect of platelet-derived growth factor on cytokine-induced nitric oxide production, EUR J PHARM, 365(1), 1999, pp. 119-123
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
365
Issue
1
Year of publication
1999
Pages
119 - 123
Database
ISI
SICI code
0014-2999(19990115)365:1<119:EERART>2.0.ZU;2-4
Abstract
Cytokines and cytokine-induced nitric oxide (NO) play important roles in in flammatory glomerular diseases, and both platelet-derived growth factor and transforming growth factor-beta inhibit cytokine-induced NO production. In this study, we demonstrated that a selective endothelin ETA receptor antag onist, BQ-485 (Hexahydro-1H-azepinylcarbonyl-Leu-D-Trp-D-Trp-OH), reversed the inhibitory effect of platelet-derived growth factor on cytokine-induced NO production, but not that of transforming growth factor-beta. Our findin gs suggest. a difference between the inhibitory mechanisms of platelet-deri ved growth factor and transforming growth factor-beta on cytokine-induced N O production. (C) 1999 Elsevier Science B.V. All rights reserved.