Spatial orientation is based on coordinates referring to the subject's body
. A fundamental principle is the mid-sagittal plane, which divides the body
and space into the left and right sides. Its neural bases were investigate
d by functional magnetic resonance imaging (fMRI). Seven normal subjects pr
essed a button when a vertical bar, moving horizontally, crossed the subjec
tive mid-sagittal plane. In the control condition, the subjects' task was t
o press a button when the direction of the bar movement changed, at the end
of each leftward or rightward movement. The task involving the computation
of the mid-sagittal plane yielded increased signal in posterior parietal a
nd lateral frontal premotor regions, with a more extensive activation in th
e right cerebral hemisphere. This direct evidence in normal human subjects
that a bilateral, mainly right hemisphere-based, cortical network is active
during the computation of the egocentric reference is consistent with neur
opsychological studies in patients with unilateral cerebral lesions. Damage
to the right hemisphere, more frequently to the posterior-inferior parieta
l region, may bring about a neglect syndrome of the contralesional, left si
de of space, including a major rightward displacement of the subjective mid
-sagittal plane. The existence of a posterior parietal-lateral premotor fro
ntal network concerned with egocentric spatial reference frames is also in
line with neurophysiological studies in the monkey.