Thrombin: A novel renal growth factor

Glomerular fibrin deposition is a common histopathological finding in a var iety of glomerular diseases and suggests the intraglomerular activation of the coagulation system, The activation of thrombin is the last step in the coagulation cascade, On the basis of its ability to modulate several cell f unctions through the activation of different receptors and intracellular-si gnaling pathways, thrombin could be considered as a growth factor more than as a simple coagulation factor, Indeed, this multifunctional serine protea se may represent the link between the activation of the coagulation cascade and the inflammatory and profibrotic response at the glomerular level. Thi s review will focus on the potential role of thrombin in the pathogenesis o f glomerular damage and on the mechanisms underlying the cellular effects o f this serine protease.