In the eighties the 'method of treatment proven in many thousands of cases
over 20 years' was transferred from the USA to Germany (enjoys a priori con
siderable faith) using very dubious promises. It: was Clarke et al. who int
roduced this 'therapy' in 1955. The dubious promise was to maintain that th
e chelation therapy eliminates or alleviates symptoms in the case of the fo
llowing illnesses: Alzheimer's disease, senility, schizophrenia, rheumatoid
arthritis, osteoarthritis, gout, renal calculus, apoplectic coma, gallston
es, multiple sclerosis, osteoporosis, chronic fatigue syndrome, varicose ve
ins, hypertension, failure of memory, scleroderma, Raynaud's disease, digit
alis intoxication, intermittent claudication, diabetic ulcer, disturbance o
f the blood supply, ulcer on the legs snake poison, impotence, emotional di
fficulties, defective hearing, vision disorder. There is not the slightest
proof of effectiveness for any of the listed indications. The burden of pro
of lies with the supplier.
Even in the case of the relatively often examined peripheral atheroscleroti
c changes (claudicatio intermittens) there is no proof that EDTA has a grea
ter effect than placebo. For coronary heart disease too there is no evidenc
e for any usefulness of the chelation therapy beyond that of a placebo effe
ct. Only controlled studies can help to improve the therapy in the sense of
'Evidence-based medicine'. Retrospective investigations on thousands of pa
tients cannot 'prove' anything, although this is maintained again and again
.