Prognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1

Background & Aims: Risk factors of metachronous river metastases and death are not well known in patients with the Zollinger-Ellison syndrome and mult iple endocrine neoplasia type 1. These factors were retrospectively determi ned in 77 patients. Methods: Data chart review was performed. Results: Medi an follow-up was 102 months (range, 12-366). Surgery was performed on 48 pa tients, including 9 of the 10 patients with large pancreatic tumors (greate r than or equal to 3 cm). Liver metastases developed in 4 patients (40%) wi th large pancreatic tumors, in 3 (4.8%) without, and in 1 of the 4 patients with pancreatic tumors of unknown size; all had previously undergone surge ry. The only independent factor associated with development of river metast ases identified by multivariate analysis was large pancreatic tumors (risk ratio, 29.0; 95% confidence interval [CI], 3.2-260.7). Surgery was not sele cted. The probability of being free of liver metastases in the 63 patients without large pancreatic tumors was 96% (95% CI, 88-100) at 10 and 15 years . Thirteen (16.9%) patients died. The only independent factors of death sel ected by multivariate analysis were Zollinger-Ellison syndrome diagnosis be fore 1980 (risk ratio, 8.2; 95% CI, 1.7-40.6) and age at diagnosis (risk ra tio/year, 1.08; 95% CI, 1.03-1.14). Conclusions: Large pancreatic tumors ar e predictive of the development of metachronous liver metastases, and surge ry does not seem to prevent them.