Nx. Nguyen et al., Quantification of blood-aqueous barrier breakdown after photorefractive keratectomy for myopia, GR ARCH CL, 237(2), 1999, pp. 113-116
Citations number
19
Categorie Soggetti
Optalmology
Journal title
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Background: Photorefractive keratectomy (PRK) using the excimer laser is a
well-established surgical technique for correction of mild to moderate myop
ic refraction errors in case of spectacle or contact lens incompatibility.
As it is still uncertain whether this procedure causes intraocular inflamma
tory changes, it was the purpose of this study to quantify breakdown of the
blood-aqueous barrier following PRK and to look for possible correlations
with clinical parameters. Patients and methods: Aqueous flare was quantifie
d using the laser flare-cell meter after medical pupil dilation preoperativ
ely and on days 1, 3 and 7 as well as 1 month and 3 months following PRK wi
th a 193-nm excimer laser (MEL 60, Aesculap-Meditec) in 37 eyes of 22 patie
nts. The preoperative spherical equivalents were -4.4+/-3.1 D (range -1.5 t
o -8.0 D). Pre-, intra- and postoperative treatment was standardized, Resul
ts: Preoperatively, aqueous flare values were 3.9+/-0.8 photon counts/ms an
d showed no significant correlation with the spherical equivalent (p>0.1).
Postoperatively, aqueous flare rise was very small with flare values not si
gnificantly higher than preoperative values. All postoperative flare values
were below the normal limit( <8.0 photon counts/ms). Flare was highest on
day 3 after PRK surgery. There was no statistically significant correlation
between aqueous flare and depth of stromal ablation. The number of aqueous
"cells" did not increase following PRK at any postoperative follow-up exam
ination, Conclusion: Our results indicate that PRK in mild to moderate myop
ia does not cause a significant breakdown of the blood-aqueous barrier.