Role of lipids, lipoproteins and lipid peroxidation in thrombocytopenia inpatients with vivax malaria

Possible roles of oxidative and metabolic changes of lipids in the developm ent of thrombocytopenia in patients with vivax malaria were investigated. S erum total cholesterol, HDL and LDL cholesterols, triglycerides, lipid pero xidation level and platelet counts were determined in 60 patients with viva x malaria and compared with 50 healthy individuals. Inter-relationships of parameters were investigated. In patients, serum total cholesterol, HDL and LDL cholesterol concentrations and platelet counts were lower, and serum t riglycerides and plasma lipid peroxidation concentrations were higher than those of control subjects. Significant relationships were found among serum lipid parameters, plasma lipid peroxidation and thrombocyte counts. Decrea se in total cholesterol, HDL and LDL cholesterols and platelet counts may b e related or secondary to oxidative stress. In the treatment of thrombocyto penia required in the some cases of malaria, the supplementation of antioxi dative vitamins may be considered.