Synthesis of reversible nucleoside amino acid conjugates

Authors
Sondhi, SM Xie, J Modak, AS Bashkin, JK
Citation
Sm. Sondhi et al., Synthesis of reversible nucleoside amino acid conjugates, I J CHEM B, 37(11), 1998, pp. 1097-1103
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
37
Issue
11
Year of publication
1998
Pages
1097 - 1103
Database
ISI
SICI code
0376-4699(199811)37:11<1097:SORNAA>2.0.ZU;2-O
Abstract
A general synthetic method to conjugate cysteine-containing peptides to nuc leosides via a disulfide link has been developed, using the heterobifunctio nal reagent N-succinimidyl-3-(2-pyridylthio)propionate(SPDP) and amino-modi fied nucleosides. Representative compounds based on C-6 modified adenosine, C-5 modified uridine and 2'-deoxyuridine are reported, along with extensiv e NMR characterizations of these novel nucleosides.