Synthesis, Dimroth rearrangement and blood platelet disaggregation property of pyrimido[4 ',5 ': 4,5]selenolo [2,3-b]quinolines: A new class of condensed quinoline

Authors
Nandeeshaiah, SK Ambekar, SY Krishnakantha, TP
Citation
Sk. Nandeeshaiah et al., Synthesis, Dimroth rearrangement and blood platelet disaggregation property of pyrimido[4 ',5 ': 4,5]selenolo [2,3-b]quinolines: A new class of condensed quinoline, I J CHEM B, 37(10), 1998, pp. 995-1000
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
37
Issue
10
Year of publication
1998
Pages
995 - 1000
Database
ISI
SICI code
0376-4699(199810)37:10<995:SDRABP>2.0.ZU;2-J
Abstract
Compounds containing 4-aminoselenolo[3,2-d] pyrimidine in a novel tetracycl ic condensed quinoline system viz. pyrimido[4',5':4,5]selenolo [2,3-b]quino line have been synthesized. Dimroth rearrangement of this new condensed dia zine system is studied. Biological study shows that while all compounds are active against collagen induced blood platelet aggregation, they are found to be inactive against ADP induced blood platelet aggregation.