Role-of lipopolysaccharide sialylation in serum resistance of serogroup B and C meningacoccal disease isolates

Authors
Vogel, U Claus, H Heinze, G Frosch, M
Citation
U. Vogel et al., Role-of lipopolysaccharide sialylation in serum resistance of serogroup B and C meningacoccal disease isolates, INFEC IMMUN, 67(2), 1999, pp. 954-957
Citations number
31
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
2
Year of publication
1999
Pages
954 - 957
Database
ISI
SICI code
0019-9567(199902)67:2<954:RLSISR>2.0.ZU;2-I
Abstract
alpha-2,3-Sialyltransferase mutants of three genetically and phenotypically diverse Neisseria meningitidis strains were compared with regard to resist ance to human serum and systemic spread in the infant rat. Lipopolysacchari de sialylation was found to be of minor importance for the resistance of se rogroup B and C meningococcal disease isolates to complement attack.