Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B-abortus

Authors
Onate, AA Vemulapalli, R Andrews, E Schurig, GG Boyle, S Folch, H
Citation
Aa. Onate et al., Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B-abortus, INFEC IMMUN, 67(2), 1999, pp. 986-988
Citations number
14
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
2
Year of publication
1999
Pages
986 - 988
Database
ISI
SICI code
0019-9567(199902)67:2<986:VWLECE>2.0.ZU;2-7
Abstract
Vaccination of mice with Escherichia coli expressing Brucella Cu/Zn superox ide dismutase (SOD) [E. coli (pBSSOD)] induced a significant level of prote ction against virulent Brucella abortus challenge, although this level was not as high as the one reached with B. abortus vaccine strain RB51. In addi tion, vaccination with E. coli(pBSSOD)) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro wi th a thioredoxin-Cu/Zn SOD fusion protein.