Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: Fermentation, isolation and biological activity

Authors
Komaki, H Nemoto, A Tanaka, Y Takagi, H Yazawa, K Mikami, Y Shigemori, H Kobayashi, J Ando, A Nagata, Y
Citation
H. Komaki et al., Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: Fermentation, isolation and biological activity, J ANTIBIOT, 52(1), 1999, pp. 13-19
Citations number
25
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
52
Issue
1
Year of publication
1999
Pages
13 - 19
Database
ISI
SICI code
0021-8820(199901)52:1<13:BAANTA>2.0.ZU;2-X
Abstract
A novel tricyclic diterpenoid antibiotic, brasilicardin A, was isolated fro m the culture broth of Nocardia brasiliensis IFM 0406. The antibiotic exhib ited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC50 value was 0.057 mu g/ml. Although the inhibitory activity of cyclosporin A (CyA) against IL-2 production was confirmed in th e MLR assay system, brasilicardin A did not have the activity. The results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.