Growth and production kinetics of a teicoplanin producing strain of Actinoplanes teichomyceticus

The growth and production kinetics of a teicoplanin producing strain of Act inoplanes teichomyceticus (ATCC 31121) was investigated during batch cultiv ations on defined media. The growth was characterised by two exponential gr owth phases (EGPs), with a higher specific growth rate in the first than in the second phase, also the specific rate of formation of teicoplanin was s ignificantly fewer in the second phase than in the first phase. This two-ph ased growth pattern was suggested to be caused by inhibition of growth by t eicoplanin accumulated. Furthermore high concentrations of ammonia or phosp hate reduced both the specific growth rate in the first EGP and the total p roduction of teicoplanin.