Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: A preliminary report

Citation
Fa. Syed et Sa. Chalew, Ketoconazole treatment of gonadotropin independent precocious puberty in girls with McCune-Albright syndrome: A preliminary report, J PED END M, 12(1), 1999, pp. 81-83
Citations number
13
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
ISSN journal
0334018X → ACNP
Volume
12
Issue
1
Year of publication
1999
Pages
81 - 83
Database
ISI
SICI code
0334-018X(199901/02)12:1<81:KTOGIP>2.0.ZU;2-D
Abstract
McCune-Albright syndrome (MAS) in girls is characterized by gonadotropin in dependent precocious puberty (GIPP), This form of GIPP is resistant to ther apy with GnRH analogues. As an alternative treatment, we successfully used ketoconazole 200 mg t.i.d. orally in two girls with MAS, GIPP and advanced bone age Ketoconazole led to rapid control of GIPP with cessation of menses and regression of pubertal signs in both patients. Ketoconazole was tempor arily interrupted in one patient due to pruritis but later restarted withou t problem. After 1 year of therapy both patients have remained free of mens es, progression of puberty and other side effects. Repeat sonography on ket oconazole revealed continued presence of ovarian cysts. Our preliminary exp erience indicates the safety and effectiveness of ketoconazole as a therapy for GIPP with potential advantages over previously used modes of treatment . Longer use of ketoconazole to suppress GIPP is required to determine whet her this therapy can prolong linear growth with enhancement of final height .