The role of TEL fusion genes in pediatric leukemias

Authors
Rubnitz, JE Pui, CH Downing, JR
Citation
Je. Rubnitz et al., The role of TEL fusion genes in pediatric leukemias, LEUKEMIA, 13(1), 1999, pp. 6-13
Citations number
84
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA
ISSN journal
08876924 → ACNP
Volume
13
Issue
1
Year of publication
1999
Pages
6 - 13
Database
ISI
SICI code
0887-6924(199901)13:1<6:TROTFG>2.0.ZU;2-I
Abstract
The TEL and AML1 genes are common targets of chromosomal translocations in hematopoietic malignancies. The TEL-AML1 fusion gene, created by the t(12;2 1), is the most common genetic alteration in childhood acute lymphoblastic leukemia and is associated with a favorable outcome. This review summarizes the roles of the TEL and AML1 proteins in hematopoiesis, the potential tra nsforming mechanisms of TEL fusion proteins, and the clinical significance of the TEL-AML1 fusion.