Patient motion during the acquisition of a magnetic resonance image can cau
se blurring and ghosting artifacts in the image. This paper presents a new
post-processing strategy that can reduce artifacts due to in-plane, rigid-b
ody motion in times comparable to that required to re-scan a patient. The a
lgorithm iteratively determines unknown patient motion such that correction
s for this motion provide the best image quality, as measured by an entropy
-related focus criterion. The new optimization strategy features a multi-re
solution approach in the phase-encode direction, separate successive one-di
mensional searches for rotations and translations, and a novel method requi
ring only one re-gridding calculation for each rotation angle considered, A
pplicability to general rigid-body in-plane rotational and translational mo
tion and to a range of differently weighted images and k-space trajectories
is demonstrated. Motion artifact reduction is observed for data from a pha
ntom, volunteers, and patients. Magn Reson Med 41:163-170, 1999. (C) 1999 W
iley-Liss, Inc.