Does captopril have a direct pro-apoptotic effect?

Citation
M. Buemi et al., Does captopril have a direct pro-apoptotic effect?, NEPHRON, 81(1), 1999, pp. 99-101
Citations number
16
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
NEPHRON
ISSN journal
00282766 → ACNP
Volume
81
Issue
1
Year of publication
1999
Pages
99 - 101
Database
ISI
SICI code
0028-2766(199901)81:1<99:DCHADP>2.0.ZU;2-F
Abstract
The beneficial effect of ACE inhibitors on cardiovascular remodelling from hypertension and ischemic disease may be due to the effect of these drugs o n the proliferation/cell death balance. We therefore investigated the effec t of the addition of captopril in vitro, on the onset of apoptosis in human vascular myocytes, by using a propidium iodide fluorescence analysis and a morphological analysis using the acridine orange technique. Captopril (0.2 3 mM) caused an increase in apoptotic phenomena that was more than 3.5-fold than in controls both at the 24th (7.7 vs. 2%) and the 48th h (10.1 vs. 3. 8%). The addition of propranolol strengthened the effect on apoptosis. The induction of apoptotic phenomena may be a mechanism by which ACE inhibitors affect cardiovascular remodelling and it might also explain the favorable effect these drugs have on diseases such as IgA nephropathy and diabetic ne phropathy.