Diaphragma sellae meningiomas are unusual tumours often not distinguished f
rom pituitary macroadenomas. Preoperative differentiation is essential, bec
ause the trans-sphenoidal approach is used for surgical removal of adenomas
, while meningiomas are approached via a craniotomy. We reviewed five patie
nts in whom a diaphragma sellae meningioma was initially diagnosed as a non
secreting pituitary macroadenoma. MRI criteria for differential diagnosis a
re discussed, The main findings considered are visibility of the pituitary
gland, contrast enhancement, the centre of the lesion and sellar enlargemen
t, These criteria, applied to a blind review, allow correct identification
of the tumours.