Marchiafava-Bignami disease with widespread extracallosal lesions and favourable course

We report a 61-year-old alcoholic man who presented with subacute physical deterioration and severe dysarthria, MRI, suggestive of corpus callosum dem yelination with associated white matter involvement in both cerebral hemisp heres, indicated the diagnosis of Marchiafava-Bignami disease. During his s tay in hospital the patient showed remarkable improvement, and was discharg ed 22 days after admission. On MRI 2 months later, the extracallosal lesion s had disappeared. This case raises questions about some previous ideas on this disease, such as the prognosis of its acute forms and the significance of the extracallosal lesions seen on neuroimaging.