Effect of age and nerve injury on cross-excitation among sensory neurons in rat dorsal root ganglia

Citation
Cn. Liu et al., Effect of age and nerve injury on cross-excitation among sensory neurons in rat dorsal root ganglia, NEUROSCI L, 259(2), 1999, pp. 95-98
Citations number
14
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
259
Issue
2
Year of publication
1999
Pages
95 - 98
Database
ISI
SICI code
0304-3940(19990108)259:2<95:EOAANI>2.0.ZU;2-A
Abstract
Spike activity in dorsal root ganglion (DRG) neurons depolarizes passive ne ighbors that share the same ganglion. We asked whether age or prior nerve i njury affect this 'cross-depolarization' signal. Intracellular recordings m ade from excised DRGs in vitro revealed that the prevalence and duration of cross-depolarization were no greater in adult than in young rats, and that its amplitude was significantly smaller in adults. The amplitude of cross- depolarization was not affected by nerve injury. The decrease in membrane i nput resistance (R-in) observed during cross-depolarization was less than t hat expected from equivalent depolarization alone. This affirms prior evide nce that the neural process underlying cross-depolarization causes a net in crease in R-in. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.