Transient acute myopia induced by antilymphocyte globulins

Acute onset of transient myopia may be induced by several drugs, different mechanisms having been described. We report the occurrence of such an event after intravenous administration of equine antilymphocyte globulins in a p atient treated for aplastic anemia. Clinical ocular examination revealed no other abnormality, and ultrasonography disclosed no swelling of the ciliar y body. The drug-induced myopia resolved completely after instillation of t opical cyclopentolate, suggesting that its mechanism was the occurrence of a ciliary spasm. Acute myopia is a rare event and, to the authors' knowledg e, this represents the first case described as being induced by antilymphoc yte globulins.