Hyalinizing clear cell carcinoma of the oral cavity and of the parotid gland

Hyalinizing clear cell carcinoma (HCCC) is a ra re, recently described tumo r of salivary gland origin. Differential diagnosis includes benign lesions as clear cell change in a pleomorphic adenoma or in oncocytoma and malignan t tumors- i.e. epithelial-myoepithelial carcinoma, polymorphous low-grade a denocarcinoma, mucoepidermoid carcinoma, clear cell acinic carcinoma, clear cell squamous carcinoma, clear cell malignant melanoma, clear cell odontog enic carcinoma, clear cell rhabdomyosarcoma, sebaceous carcinoma and metast asis of renal carcinoma, A favorable prognosis after wide local excision ha s been evidenced. Th ree new cases of HCCC (2 in the oral cavity and 1 in t he parotid gland) are presented.