Plasma membrane redox system activity in tumour cell lines of mammary origins with different proliferation rates

Plasma membrane redox systems seem to play a role in the control of cell gr owth. In fact, we have found that in mammary tumour cell lines the increase in the proliferation rare is accompanied by a decrease in the plasma membr ane redox activity. The oxygen consumption rates, the glycolytic fluxes and other bioenergetic parameters have been studied in two cell strains of Ehr lich ascites tumour with different proliferation rates. In the more prolife rative Ehrlich cell strain, the decrease in plasma membrane redox system ac tivity is accompanied by decreased oxygen consumption and glycolytic flux a nd to a generally less energised status.