Among unipolar mood disorders, major depressive disorder (MDD) has traditio
nally been the most widely studied. There is, however, an alarming lack of
extant research on the more mild mood disorders. Recent findings indicate t
hat, collectively, milder unipolar mood disorders, such as dysthymic disord
er (DD), and conditions specific to women, such as premenstrual dysphoric d
isorder (PMDD) and postpartum depression, functionally impair a large popul
ation of women. The course, mechanisms, and treatments of these illnesses a
re outlined, and specific areas of concern, including current available tre
atment applicability, gender differences In psychiatric testing, and the us
e of biological markers for the detection of illness, are detailed. Directi
ons for future research are presented.