This article presents two algorithms dealing with the management of schizop
hrenia, One provides a strategy for initiating pharmacologic treatment of s
chizophrenia and for ongoing medication management. The other covers sugges
tions for managing several common comorbid psychiatric conditions and some
common side effects. The major change from previous algorithms is the sugge
stion that the newer atypical antipsychotic agents may now be the treatment
of choice for initiating therapy in most clinical situations.