Depression in pediatric chronic illness has been receiving increasing atten
tion in recent years. Studies to date have typically focused on characteris
tics of illness as the major determinants of the development of depression,
but characteristics of the child have received less attention. This review
suggests that a diathesis-stress model can be a fruitful heuristic that wo
uld incorporate illness characteristics and attributes of the child and env
ironmental effects in an overall framework to guide future research and tre
atment.