Enantioselective synthesis of dityrosine and isodityrosine via asymmetric phase-transfer catalysis.

Authors
Lygo, B
Citation
B. Lygo, Enantioselective synthesis of dityrosine and isodityrosine via asymmetric phase-transfer catalysis., TETRAHEDR L, 40(7), 1999, pp. 1389-1392
Citations number
34
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
7
Year of publication
1999
Pages
1389 - 1392
Database
ISI
SICI code
0040-4039(19990212)40:7<1389:ESODAI>2.0.ZU;2-6
Abstract
Application of N-anthracenylmethyl cinchonidinium chloride quaternary ammon ium phase-transfer catalysts to the enantio- and diastereoselective synthes is of dityrosine and isodityrosine is reported. Under liquid-liquid phase-t ransfer conditions the key alpha-amino acid substituents are introduced wit h high enantioselectivity (greater than or equal to 95%e.e.). (C) 1999 Else vier Science Ltd. All rights reserved.