Split-split. A multiple synthesiser approach to efficient automated parallel synthesis

Authors
Brooking, P Doran, A Grimsey, P Hird, NW MacLachlan, WS Vimal, M
Citation
P. Brooking et al., Split-split. A multiple synthesiser approach to efficient automated parallel synthesis, TETRAHEDR L, 40(7), 1999, pp. 1405-1408
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
7
Year of publication
1999
Pages
1405 - 1408
Database
ISI
SICI code
0040-4039(19990212)40:7<1405:SAMSAT>2.0.ZU;2-Y
Abstract
A multiple synthesiser approach to high efficiency, high throughput synthes is is described. It involves eliminating duplication in multi-step synthesi s by establishing a cascade of matched synthesisers in which each machine p erforms a single step and provides feedstocks for the next instrument. The utility of this approach is illustrated by the efficient construction of a large array by a 4 step solution synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.