A new irregular diterpene skeleton from Anisotome flexuosa.

Authors
van Klink, JW Barlow, AJ Perry, NB Weavers, RT
Citation
Jw. Van Klink et al., A new irregular diterpene skeleton from Anisotome flexuosa., TETRAHEDR L, 40(7), 1999, pp. 1409-1412
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
7
Year of publication
1999
Pages
1409 - 1412
Database
ISI
SICI code
0040-4039(19990212)40:7<1409:ANIDSF>2.0.ZU;2-8
Abstract
A novel class of irregular diterpene has been discovered in the New Zealand subalpine plant Anisotome flexuosa Dawson (Apiaceae/Umbelliferae). The str ucture and relative stereochemistry of anisotomenoic acid 4 (3,3a,4,4-tetra methyl-3-(4-methyl-3-pentenyl)-2,3,3a,4,5,6-hexahydro-1H-2-indenecarboxylic acid) was determined by NMR correlation experiments conducted on 4 and a p rimary alcohol derivative 5 (3,3a,4,4-tetramethyl-3-(4-methyl-3-pentenyl)-2 ,3,3a,4,5,6-hexahydro-1H-2-indenyl) methanol). Alcohol 5 was subsequently c onfirmed as a natural product. (C) 1999 Elsevier Science Ltd. All rights re served.