A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides

Authors
Faul, MM Winneroski, LL Krumrich, CA
Citation
Mm. Faul et al., A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides, TETRAHEDR L, 40(6), 1999, pp. 1109-1112
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
6
Year of publication
1999
Pages
1109 - 1112
Database
ISI
SICI code
0040-4039(19990205)40:6<1109:ANOSSO>2.0.ZU;2-A
Abstract
Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. T he mechanism of the reaction is discussed. (C) 1999 Published by Elsevier S cience Ltd. All rights reserved.