Convergent synthesis of S-8921, a new potent hypocholesterolemic arylnaphthalene lignan analog

Authors
Mori, S Takechi, S Shimizu, S Kida, S Iwakura, H Hajima, M
Citation
S. Mori et al., Convergent synthesis of S-8921, a new potent hypocholesterolemic arylnaphthalene lignan analog, TETRAHEDR L, 40(6), 1999, pp. 1165-1168
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
6
Year of publication
1999
Pages
1165 - 1168
Database
ISI
SICI code
0040-4039(19990205)40:6<1165:CSOSAN>2.0.ZU;2-0
Abstract
We established a convergent synthesis of S-8921 (1), a unique hypocholester olemic lignan analog, in 9 steps, including concise preparations of phthali de 7 and acylpropenoate 10, and their regio- and stereocontrolled tandem an ionic reactions leading to precursor 11 as a key step. (C) 1999 Elsevier Sc ience Ltd. All rights reserved.