High yields of meta-substituted amination products in the SNAr substitution of benzenes

Authors
Brown, GR Foubister, AJ Ratcliffe, PD
Citation
Gr. Brown et al., High yields of meta-substituted amination products in the SNAr substitution of benzenes, TETRAHEDR L, 40(6), 1999, pp. 1219-1222
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
6
Year of publication
1999
Pages
1219 - 1222
Database
ISI
SICI code
0040-4039(19990205)40:6<1219:HYOMAP>2.0.ZU;2-#
Abstract
Morpholine substitution in fluorobenzenes containing a meta-substituted ele ctron withdrawing group proceeds in DMSO at 100 degrees C over 60 h to give meta-substitution products (by fluoride ion displacement) in pure isolated yields of 19-98%. (C) 1999 Elsevier Science Ltd. All rights reserved.