Inhibition of the non-mevalonate 1-deoxy-D-xylulose-5-phosphate pathway ofplant isoprenoid biosynthesis by fosmidomycin

Authors
Zeidler, J Schwender, J Muller, C Wiesner, J Weidemeyer, C Beck, E Jomaa, H Lichtenthaler, HK
Citation
J. Zeidler et al., Inhibition of the non-mevalonate 1-deoxy-D-xylulose-5-phosphate pathway ofplant isoprenoid biosynthesis by fosmidomycin, Z NATURFO C, 53(11-12), 1998, pp. 980-986
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
ISSN journal
09395075 → ACNP
Volume
53
Issue
11-12
Year of publication
1998
Pages
980 - 986
Database
ISI
SICI code
0939-5075(199811/12)53:11-12<980:IOTN1P>2.0.ZU;2-3
Abstract
Various bacterial and plastidic plant terpenoids are synthesized via the no n-mevalonate 1-deoxy-D-xylulose-5-phosphate (DOXP) pathway. The antibiotic and herbicidal compound tosmidbmycin is known to inhibit growth of several bacteria and plants, but so far its mode of action was unknown. Here we pre sent data which demonstrate that the DOXP pathway of isoprenoid biosynthesi s is efficiently blocked by fosmidomycin. The results point to the DOXP red uctoisomerase as the probable target enzyme of fosmidomycin.