Increased levels of lipid oxidation products in rheumatically destructed bones of patients suffering from rheumatoid arthritis

The new indicator for lipid peroxidation (LPO) processes - 9-hydroxy-10,12- octadecadienoic acid (9-MODE) - was used to investigate, whether LPO proces ses are increased in destructed bone material of patients suffering from rh eumatoid arthritis (RA) in comparison to surrounded non destructed bone mat erial. The HODE content in destructed bones exceeded that of non destructed ones of the same patient for a factor of about 3. In addition similar increases in leukotoxines and epoxy oleic acid in the d estructed bone material were observed, indicating an increase of LPO proces ses in affected bone parts of patients.