Metal complexes with biologically important ligands, CIX - Organometallic compounds of platinum(II), ruthenium(II), rhodium(III), and iridium(III) with oxocarbonyl-N-protected alpha-amino acids and L-methionylglycinate

The reaction of cis-(Ph3P)(2)PtCl2 with BOC-N-glycine and FMOC-N-alanine gi ves the carboxylate coordinated complexes cis-(Ph3P)(2)Pt(Cl)(O2CCH2NHBOC) (1) and cis-(Ph3P)(2)Pt(Cl)(O2CC(H)(Me)NHFMOC (2). Chloride and proton abst raction from 1 affords the N,O-chelate complex (Ph3P)(2)Pt(O2CCH2NBOC) (3). From the chloro-bridged compounds [Cp*MCl2](2) (M = Rh, Lr), [(p-cymene)Ru Cl2](2) and BOC-N-L-MetGlyOH (L) the compounds Cp*M(Cl)(2)L (4, 5) and p-cy mene)Ru(Cl)(2)L (6) with the mono-dentate dipeptide are obtained which in t he presence of NaOMe form O,N,S-bis(chelate) complexes 7 - 9. The X-ray dif fraction analysis of the iridium O,N,S chelate complex 8 shows a five membe red and a seven membered chelate ring.