COMBINATION EFFECT OF GRANISETRON AND METHYLPREDNISOLONE FOR PREVENTING EMESIS INDUCED BY CYTOTOXIC AGENTS

Authors
KIGAWA J MINAGAWA Y ITAMOCHI H CHENG XS OKADA M TERAKAWA N
Citation
J. Kigawa et al., COMBINATION EFFECT OF GRANISETRON AND METHYLPREDNISOLONE FOR PREVENTING EMESIS INDUCED BY CYTOTOXIC AGENTS, Gynecologic and obstetric investigation, 43(3), 1997, pp. 195-199
Citations number
18
Categorie Soggetti
Obsetric & Gynecology
Journal title
Gynecologic and obstetric investigation → ACNP
ISSN journal
03787346
Volume
43
Issue
3
Year of publication
1997
Pages
195 - 199
Database
ISI
SICI code
0378-7346(1997)43:3<195:CEOGAM>2.0.ZU;2-5
Abstract
To evaluate the combined effect of granisetron and methylprednisolone against acute emesis induced by cytotoxic agents, we investigated the clinical response and the urinary excretion of 5-HIAA in 85 patients w ith ovarian cancer who received the same anticancer chemotherapeutic r egimen in a prospective randomized trial. Each patient received one of three different regimens (granisetron alone, methylprednisolone plus granisetron, and metoclopramide alone). The combination therapy of gra nisetron and methylprednisolone is effective for preventing acute emes is induced by cytotoxic chemotherapy.