17,17-Ethylenedioxyandrost-4-ene-3,6-dio and 17,17-ethylenedioxyandrosta-1,4-diene-3,6-dione

Authors
Anthony, A Jaskolski, M Nangia, A Desiraju, GR
Citation
A. Anthony et al., 17,17-Ethylenedioxyandrost-4-ene-3,6-dio and 17,17-ethylenedioxyandrosta-1,4-diene-3,6-dione, ACT CRYST C, 54, 1998, pp. 1894-1898
Citations number
15
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
54
Year of publication
1998
Part
12
Pages
1894 - 1898
Database
ISI
SICI code
0108-2701(199812)54:<1894:1A1>2.0.ZU;2-8
Abstract
The crystal structures of 17,17-ethylenedioxyandrost-4-ene-3,6-dione, C21H2 8O4, and 17, 17-ethylenedioxy-androsta-1,4-diene-3,6-dione, C12H26O4, inter mediates in the synthesis of heteroandrogenic aromatase inhibitors, have be en determined. Both structures are stabilized by C-H ... O hydrogen bonds, highlighting the importance of weak interactions in influencing packing mot ifs in general and the conformation of the flexible dioxolane ring in parti cular.