Evaluation of markers on human chromosome 10, including the homologue of the rodent Rf-1 gene, for linkage to ESRD in black patients

There is abundant evidence supporting the contribution of genetic factors t o the development of end-stage renal disease (ESRD) in blacks. Two renal fa ilure susceptibility genes, Rf-1 and Rf-2, have been identified in the fawn -hooded rat, an animal model of hypertension and nephrosclerosis, The human homologous region containing the rodent Rf-1 gene has been localized to ch romosome 10q. We tested for genetic linkage between 21 polymorphic markers on human chromosome 10 and chronic renal failure in 129 black sibling pairs concordant for ESRD. Two adjacent markers on 10p, D10S1435 and D10S249 (4 centiMorgans from D10S1435), approached significance for linkage to ESRD in sibling pairs with nondiabetic causes of ESRD (P = 0.035 pairwise, P = 0.0 82 multipoint for D10S1435; P = 0.074 pairwise, P = 0.063 multipoint for D1 0S249). The markers spanning the homologous region of Rf-1 did not show evi dence for linkage to ESRD in sibling pairs concordant for diabetic ESRD, si bling pairs concordant for nondiabetic causes of ESRD, or in the entire fam ily set. These results suggest that the human homologue of Rf-1 is unlikely to contribute substantially to renal failure susceptibility from the commo n causes of kidney disease in blacks. (C) 1999 by the National Kidney Found ation, Inc.