No association between the intronic presenilin 1 polymorphism and Alzheimer's disease in the Chinese population

Wragg et al, [1996: Lancet 347:509-512] recorded an association between the intron-based presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's di sease (AD). This study was performed to determine if there is a similar ass ociation in the Chinese population. Ninety-one AD cases, 50 multiinfarct de mentia (MID) patients, and 73 age-matched normal controls were recruited. G enotyping of PS1 and apolipoprotein E (APOE) was performed by the methods o f polymerase chain reaction and restriction fragment length polymorphism, I n AD, MID, and normal controls PS1 allele 1 frequency was 0.6703, 0.5600, a nd 0.6301, respectively; PS1 allele 2 frequency was 0.3297, 0.4400, and 0.3 699, respectively. No association was detected between these diseases and a ny PS1 allele or genotype, There was only a nearly significant negative ass ociation between MID and PS1 genotype 1/1 in the subgroup population bearin g APOE allele E4 (odds ratio = 0.2753, P = 0.0776). Our results do not supp ort the conclusion that the intronic PS1 polymorphism is associated with Al zheimer's disease. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:1-3, 1999 . (C) 1999 Wiley-Liss, Inc.