Translocation of chromosomes 11 and 22 in choroidal metastatic Ewing sarcoma detected by fluorescent in situ hybridization

PURPOSE: To describe a patient with metastasis of Ewing sarcoma to the chor oid and the molecular genetics of the tumor. METHODS: A 26-year old woman with metastatic Ewing sarcoma developed large choroidal masses in the left eye and died 2 months later, Autopsy of the ey es was performed. Dual-color fluorescent in situ hybridization was used to detect genetic alteration in the ocular tumor with EWS and FLI-1 probes, RESULTS: Histopathology confirmed choroidal metastatic Ewing sarcoma. Molec ular analysis showed chromosomal translocation t(11;22)(q24;q12) or EWS/FLI -1 rearrangement in the malignant cells of the eye. CONCLUSIONS: Ewing sarcoma can rarely metastasize to the uvea, Molecular de tection of the t(11;22)(q24;q12) translocation in Ewing sarcoma is valuable in the differential diagnosis of small round cell tumors. (Am J Ophthalmol 1999;127:226-228, (C) 1999 by Elsevier Science Inc. All rights reserved.).